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KMID : 0545120090190020204
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Journal of Microbiology and Biotechnology
2009 Volume.19 No. 2 p.204 ~ p.207
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Antibacterial and Synergistic Activity of Isocryptomerin Isolated from Selaginella tamariscina
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Lee June-Young
Choi Yun-Jung
Woo Eun-Rhan
Lee Dong-Gun
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Abstract
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We investigated novel antibacterial and synergistic activities of isocryptomerin isolated from Selaginella tamariscina. Isocryptomerin showed potent antibacterial activity against Gram-positive and Gram-negative bacterial strains including clinical isolates of antibiotic-resistant species such as methicillinresistant Staphylococcus aureus (MRSA). Additionally, we further investigated the synergistic activity of isocryptomerin with a conventional antibiotic against MRSA. The result indicated that isocryptomerin had considerable synergistic activity in combination with cefotaxime. In summary, the present study suggests that isocryptomerin may have potential as a novel therapeutic agent for treatment of infectious diseases by not only human pathogenic bacteria but also multidrug-resistant bacteria.
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KEYWORD
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Isocryptomerin, antibacterial activity, synergistic activity
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